Tells the story of persistent pain having negative effects on brain function. This book features: philosophical and social concepts of pain; testimonials of chronic-pain patients; clinical data from pain patients' brains; advances in noninvasive brain imaging for pain patients; and, manipulation of brain function in animal models.

Beginning with a survey of fundamental concepts associated with data integration, knowledge representation, and hypothesis generation from heterogeneous data sets, this title provides a practical survey of methodologies used in biological, clinical, and public health contexts.

Presents the structure, genome, and methods of transmission that influence emergence and considers non-viral factors that favor emergence, such as animal domestication, human demography, population growth, human behavior, and land-use changes.

Provides a treatment of the deep computational ideas at the foundation of the field. This book includes exercises at the end of each chapter, ideas for student projects, and a number of new topics, such as: tree structured data, interval trees, and time-oriented medical data and their use.